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Clonazepam
Eram is indicated, primarily as an adjunct or in refractory cases, in most forms of epilepsy especially absence seizures including atypical absence seizures; myoclonic and atonic seizures, Lennox-Gastaut syndrome. For infantile spasms (including West-Syndrome) and tonic-clonic seizures it is only indicated as an adjunct or in refractory cases. Also indicated for the treatment of Panic disorder, with or without agoraphobia
Dosage for Epilepsy
Adults: Initial dosage should not exceed 1 mg/day. The maintenance dosage for
adults normally falls within the range from 4 to 8 mg.
Elderly: The lowest possible dose should be used in the elderly. It is
recommended that the initial dosage of Clonazepam should not exceed 0.5
mg/day and particular care should be taken during uptitration. Total daily dosages
should be divided into 3 or 4 doses taken at intervals throughout the day. If
necessary, larger doses may be given at the discretion of the physician, up to a
maximum of 20 mg daily. The maintenance dose should be attained after 2 to 4
weeks of treatment.
Infants and children: To ensure optimum dosage adjustment, children should be
given 0.5 mg tablets. Initial dosage should not exceed 0.25 mg/day for infants and
small children (1 to 5 years) and 0.5 mg /day for older children.
The maintenance dosage for children are as follows:
5 to 12 years: 3 to 6 mg
1 to 5 years: 1 to 3 mg
Infants (0 to 1 year): 0.5 mg to 1 mg
Dosage for Panic Disorder
Adult: The initial dose for adults with panic disorder is 0.25 mg twice daily (0.5
mg/day). An increase to 0.5 mg twice daily (1 mg/day) may be made after 3 days.
Subsequent uptitration should be made at intervals of 3 days until panic disorder
is controlled or until limited by side effects. The usual maintenance dose is 1 mg
twice daily (2 mg/day). A maximum dose of 2 mg twice daily (4 mg/day) may be
prescribed in exceptional cases. Once a stable dose is achieved, patients may
switch to a once daily dose, usually taken at bedtime.
Hepatic Impairment
Patients with severe hepatic impairment should not be treated with Clonazepam.
Patients with mild to moderate hepatic impairment should be given the lowest
possible dose
Eram 0.5 Tablet (60’s): Each box contains 60 tablets (6×10’s) in Alu-PVdC blister
pack.
Eram 1 Tablet (60’s): Each box contains 60 tablets (6×10’s) in Alu-PVdC blister
pack
Eram 2 Tablet (50’s): Each box contains 50 tablets (5×10’s) in Alu-PVdC blister
pack
